Cambridge, MA - Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis method, called UMBS-seq, was published this week in Nature ...
The Genomic and RNA Profiling core offers various RNA-seq chemistries for many sample types. Total RNA-seq: Capture of both coding and non-coding RNAs. Compatible with degraded RNA. Full-length ...
Variation in the ESR-1 gene as a prognostic marker in early breast cancer survival. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This abstract does not include a full text ...
BMS-986205, an indoleamine 2, 3-dioxygenase 1 inhibitor (IDO1i), in combination with nivolumab (nivo): Updated safety across all tumor cohorts and efficacy in advanced bladder cancer (advBC). This is ...
5-Methylcytosine (5mC) is one of the most critical epigenetic modifications in mammals that formed by DNA methyltransferase (DNMT) through adding methyl groups to the carbon-5′position of cytosine.
Commonly used sequencing approaches do not capture full information from both genetics and epigenetics. Some of these may involve separate, parallel workflows and sequencing to produce full ...
Circulating cell-free DNA (cfDNA) has been reported to contain valuable genetic and epigenetic information for the diagnosis and prognosis of cancer. However, cfDNA is also a challenging input for ...
DNA methylation is a highly studied epigenetic modification that is involved in regulating genome function and plays fundamental roles in development and disease. 1 It is linked to a broad range of ...
This image illustrates the typical steps in next-generation sequencing (excluding single-molecule sequencing methods). The process begins with isolating genomic DNA (a) and breaking it into short ...
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