The brain is shielded from many substances by the blood-brain barrier, but this shield is not impenetrable. There are immune cells in the brain called microglia that can respond to potential invaders ...

For decades, scientists have pushed the limits of microscopy to capture sharper and deeper views of the brain. Traditional light-based systems can map the cortex in detail but struggle to reach deeper ...

Our brain is a complex organ. Billions of nerve cells are wired in an intricate network, constantly processing signals, enabling us to recall memories or to move our bodies. Making sense of this ...

Millions of people who recover from infections like COVID-19, influenza and glandular fever are affected by long-lasting symptoms. These include chronic fatigue, brain fog, exercise intolerance, ...

Using advanced microscopes that capture brain cell anatomy and activity, a portion of a mouse's brain was mapped and rendered into a 3D atlas that creates new possibilities for neuroscience. When you ...

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it ...

Both for research and medical purposes, researchers have spent decades pushing the limits of microscopy to produce ever deeper and sharper images of brain activity, not only in the cortex but also in ...

Lab-grown “reductionist replicas” of the human brain are helping scientists understand fetal development and cognitive disorders, including autism. But ethical questions loom. Brain organoids, which ...

Researchers at Johns Hopkins Medicine say they have used a "zap-and-freeze" technology to watch hard-to-see brain cell communications in living brain tissue from mice and humans. Findings from the new ...

Scientists have discovered how harmful clumps inside brain cells—linked to diseases like ALS and Huntington’s—form, and found a way to break them apart. These sticky tangles of RNA develop inside tiny ...

Figure 1. Conceptual illustration of label-free, multiphoton photoacoustic microscope (LF-MP-PAM). Near-infrared femtosecond laser enable us to observe endogenous NAD(P)H of neurons in brain slice and ...