Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

TO TRAP A SNAP: In their paper, Thomas Söllner and his colleagues assigned functions to previouslly identified components of a transport pathway between various cellular compartments. Vesicles, ...

E3 ligases are enzymes that act as molecular "broker" by binding specific target proteins and coordinating the transfer of ubiquitin from an E2 enzyme. As an E3 ligase recognizes only a restricted set ...