Transmembrane helices of integrin α and β subunits have been implicated in the regulation of integrin activity. Two mutations, glycine-708 to asparagine-708 (G708N) and methionine-701 to ...

(Philadelphia, PA) - Integrin receptors allow cells to attach to other cells and to connective tissue which is necessary to form tissues, organs, or even people, for that matter. Researchers at the ...

Homomeric and heteromeric interactions between the αIIb and β3 transmembrane domains are involved in the regulation of integrin αIIbβ3 function. These domains appear to interact in the inactivated ...

Peptides were designed to examine the significance of two integrin in blood clotting. Researchers at the University of Pennsylvania School of Medicine have designed peptides that are able to bind to ...

PHILADELPHIA -- Proteins, which form much of the molecular machinery required for life, are the targets of most drug molecules. One third of all proteins are membrane proteins – embedded within the ...

Integrin receptors allow cells to attach to other cells and to connective tissue which is necessary to form tissues, organs, or even people, for that matter. Researchers at the University of ...

To probe the secrets of inaccessible transmembrane proteins, researchers at the University of Pennsylvania School of Medicine have designed peptides that are able to bind to specific inner regions, ...