The myristoylated alanine-rich C kinase substrate (MARCKS) is a pivotal signalling protein whose multifaceted roles span cytoskeletal regulation, vesicular trafficking and signal transduction. Acting ...

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

Kinases play a key role in many cellular signaling pathways and in several diseases, such as cancer and inflammation. Kinase inhibition assays comprise about 20–30% of current high-throughput ...

The central role of protein kinases in signal transduction and recent clinical success with small molecule kinase inhibitor drugs, most notably Gleevec (Novartis), have generated intense interest in ...

Protein phosphorylation is a major posttranslational modification carried out by protein kinases that constitute an integral part of complex signaling networks in eukaryotes. Casein kinase 1 (CK1) is ...

A 'pocket' on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Cell division is key for life. Every organism -- from the smallest yeast ...

A new research paper was published in Oncotarget on August 4, 2022, entitled, "Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase ...