Ligand binding affinities at G-protein coupled receptors (GPCRs) have historically been determined using a radioligand that competes for receptor binding sites against an unlabeled drug-like compound.

Binding of a ligand to the native three-dimensional configuration of a protein increases protein stability, with a corresponding increase in the protein’s melting temperature. This indirect ...

Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the ...