Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

Yale researchers discovered that an underactive mTOR pathway drives structural malformations in lissencephaly. Using patient-derived brain organoids, they showed that activating the mTOR pathway ...

Lissencephaly represents a term for a spectrum of severe and rare brain malformations caused by a failure in the migration of neurons that were supposed to reach designated positions in the cerebral ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

Yale University researchers have identified a molecular mechanism driving the structural abnormalities leading to lissencephaly that have, until recently, been elusive. Further, this research, ...

ASHLAND — On June 4, 22-year-old Mary Pederson gave birth to a son, Carter, at Framingham Union Hospital. Doctors needed to induce labor at 37 weeks because she had been diagnosed with preeclampsia, a ...

Researchers have successfully used protease inhibitors to restore to normal levels a key protein involved in early brain development. Reduced levels of that protein have been shown to cause the rare ...

A 1910 g infant was born at 41-weeks gestation to a 19-year-old gravida 1 mother after a pregnancy complicated by hydramnios and poor fetal movement. The child was delivered by a cesarean section ...

Lissencephaly refers to a rare condition in which the brain's typical folds do not develop, and brain development is disrupted. People with the condition often have intellectual disability and ...