How stomach cancer learns to grow on its own

Gastric (stomach) cancer remains one of the most common and deadly cancers in East Asia, including Korea. Yet despite its ...
Donga Science

Stomach Cancer Achieves Autonomous Growth by Self-Producing WNT Signals

Researchers have identified the mechanism by which cancer cells create their own growth signals to proliferate, independent ...
Managed Healthcare Executive

Phase 3 trial launches for novel antibody targeting integrin beta-6 in advanced lung cancer

High levels of IB6 are often found in NSCLC, making it a good target for treatment. A preclinical study found that in lung cancer, IB6 was correlated with interleukin-8 levels and promoted cancer cell ...
Clinical Trials Arena on MSN

Immuneering progresses MAPK inhibitor in lung and pancreatic cancer

The biotech will now take atebimetinib to mid- and late-stage trials in NSCLC and pancreatic cancer, respectively.
CU Boulder News & Events

Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles (Science Signaling 2023)

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors, subpopulations of cells escape ...
ascopubs.org

Molecular characterization of the Ras-MAPK pathway in metastatic breast cancer.

Uncovering the differential impact of ESR1 and PIK3CA codon variants on the clinical phenotype of metastatic breast cancer (MBC) through circulating tumor DNA (ctDNA) next-generation sequencing (NGS).