APAP-induced DILI leads to dysregulation of ammonia levels. The negative modulation of miR-873-5p restores methionine cycle activity, attenuates ammonia accumulation, and increases polyamine synthesis ...
DHFR: dihydrofolate reductase; FH2: dihydrofolic acid; FH4: tetrahydrofolic acid; MTHFD: methylenetetrahydrofolate dehydrogenase; SHMT: hydroxymethyltransferase ...