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Single-cell technique maps pre-malignant gene mutations in solid tissues

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...
ascopubs.org

Detection of BRAF mutations in melanoma: Rate of mutation detection at codon 600 using Sanger sequencing as compared to the cobas 4800 method.

Patterns of care in adjuvant systemic therapy of patients with stage III melanoma: A U.S. population-based study.
Nanowerk

Uniting DNA origami and CRISPR to enhance detection of genetic mutations in cancer diagnostics

Against this backdrop, a team led by Professor Zhang Han and Associate Professor Chen Zhi from Shenzhen University in China , has demonstrated an innovative approach that combines DNA origami, CRISPR ...
News Medical

Highly sensitive CRISPR-based method designed to detect low-frequency cancer mutations

Liquid biopsy is increasingly recognized as a promising tool for cancer detection and treatment monitoring, yet its effectiveness is often limited by the extremely low levels of tumor-derived DNA ...
EurekAlert!

Molecular testing of FLT3 mutations in hematolymphoid malignancies in the era of next-generation sequencing

The illustration of protein structure (domains) on the left side, and corresponding exons in the FLT3 gene are displayed on the right side. FMS-like tyrosine kinase 3 (FLT3) mutations represent some ...
News Medical on MSN

Liquid Biopsies Boost Lung Cancer Mutation Detection

In Brazil, the early detection of genetic alterations in lung cancer through liquid biopsies could be a valuable tool for ...

Whole-genome sequencing may optimize PARP inhibitor use for cancer patients

A whole-genome sequencing approach shows early promise over current commercial methods for identifying more patients likely ...