No field more eagerly awaits a molecular clarification for G-protein coupled receptor (GPCR) dimerization than the opioid receptor field. Extensive evidence of pharmacological and functional ...

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced "mew-opioid") receptors. What they didn't know - until now - was ...

Researchers at USF Health have discovered a new way opioid receptors can work that may lead to safer pain medications. Their findings show that certain experimental compounds can amplify pain relief ...

A new discovery shows that opioids used to treat pain, such as morphine and oxycodone, produce their effects by binding to receptors inside neurons, contrary to conventional wisdom that they acted ...

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 51 (December 23, 2014), pp. 18369-18374 (6 pages) Positive allosteric modulation of the mu-opioid ...

Together with colleagues from Shanghai, Brussels, Canada and the USA, researchers from the University of Bonn have uncovered the binding mechanism of an important pain receptor. The results facilitate ...

Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.

Opioids are some of the oldest known treatments for pain relief, but they can cause serious side effects. A team of researchers including Susruta Majumdar, a medicinal chemist and pharmacologist at ...

Scientists are racing to redesign how powerful painkillers work, aiming to keep the relief that opioids provide while ...

Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.