Immune checkpoint inhibitors (ICIs), drugs that release the immune system’s “brakes,” are meant to expose cancer to the full force of the immune system’s attack. But in most cancer patients, ICIs ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...

Analyzing complex gene networks can be as easy as one, two, three. One: Introduce CRISPR-based perturbations to large numbers of cells. Two: Measure the effects of these perturbations with single-cell ...

Scientists at Harvard University, the Broad Institute of MIT and Harvard, and MIT have developed a technology to investigate the function of many different genes in many different cell types at once, ...

When melanoma patients on the targeted drug vemurafenib stop responding to treatment, the cancer has usually found a workaround. The problem is that dozens of different genetic changes can each ...

Imagine that you want to know the plot of a movie, but you only have access to either the visuals or the sound. With visuals alone, you'll miss all the dialog. With sound alone, you will miss the ...