Strains containing gain- or loss-of-function kinase mutations were screened for the suppression or exacerbation of phenotypes resulting from the overexpression or mutation of the candidate substrates.

Protein kinases are enzymes that mediate the addition of a phosphate group to the side chain of one of three amino acids: serine, threonine, or tyrosine –a fundamental mechanism for protein regulation ...

Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...

Protein phosphorylation is a major posttranslational modification carried out by protein kinases that constitute an integral part of complex signaling networks in eukaryotes. Casein kinase 1 (CK1) is ...