Strains containing gain- or loss-of-function kinase mutations were screened for the suppression or exacerbation of phenotypes resulting from the overexpression or mutation of the candidate substrates.

Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...

Protein phosphorylation is a major posttranslational modification carried out by protein kinases that constitute an integral part of complex signaling networks in eukaryotes. Casein kinase 1 (CK1) is ...