A new technique offers a sharp picture of an elusive and ephemeral stage of a chemical’s life. By precisely measuring the energy of a molecule at the instant it morphs from one form to another, ...

The unexpected product and size change, in addition to the use of force instead of the usual heat as a reaction driver, make the study unusual. The team also discovered that, mechanistically, the ...

What are the atomic motions at enzymatic catalytic sites on the timescale of chemical change? Combined experimental and computational chemistry approaches take advantage of transition-state analogs to ...

The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state. The ...

Transition-state theory is one of the bedrocks of chemistry. Even introductory students might see a plot of potential energy versus reaction coordinate, with reactants on the left, products on the ...

Hike from one valley to another via a mountain pass, and eventually you'll come to the highest point of your journey, where you'll probably stop briefly to take in the view before descending. That ...

Designing Transition-State Inhibitors A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing ...

Professor Kwang-Hyun Cho’s research team has recently been highlighted for their work on developing an original technology for cancer reversal treatment that does not kill cancer cells but only ...