Prof. Liu Cong from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, along with collaborators, ...

Surface model of SpCas9–reverse transcriptase–pegRNA–target DNA complex. The prime editor, composed of a SpCas9 and a reverse transcriptase, reverse transcribes template sequence in pegRNA, resulting ...

Members of a new class of antivirals are being tested in U.S. clinical trials, and one has gained approval in Japan, but how ...

FairJourney Bio (FJBio), a leading global provider of antibody discovery and development services, today announced the ...

Toward the goal of efficient editing of farm animals for genetic improvements, this study explores an upgraded form of nuclease PE (uPEn). Based on the resolved structure of the NiV polymerase L-P ...

Most people have witnessed -- or rather smelled -- when a protein enzyme called sulfite reductase works its magic. This enzyme catalyzes the chemical reduction of sulfite to hydrogen sulfide. Hydrogen ...

Research captures how the GRP94 protein shields itself to make sure it forms properly and suggests a way to target it for future disease treatments. Proteins are often called the building blocks of ...

If you've ever accidentally sliced yourself on a broken glass or a piece of paper, you may have noticed that the bleeding can be hard to stop. Scientists have long wondered how the cascade of events ...

Particles (encircled in green) are spaced at a distance from the noise surrounding the nanobeads (purple), which would otherwise obscure them. Sample loss has been a persistent problem in cryo-EM, a ...

A custom-designed electron cryomicroscope operating at 100 keV promises to minimize the expense and complexity of biological structure research. Although electron cryo-microscopy (cryo-EM) has shown ...