Transmembrane proteins are essential for the survival and function of all living cells. They are involved in virtually every biological process, making them a vital target for drug development.

In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.

STEAP1 (Six-transmembrane epithelial antigen of the prostate 1), which was first found in prostate cancer, is a member of the STEAP protein family that is largely expressed in prostate epithelial ...