Astrocytes, the Gatekeepers of Norepinephrine Signaling in the …
Jun 6, 2025 · Norepinephrine modulates neuronal synapses by way of astrocyte adrenergic receptors. The astrocytes release ATP, which converts to adenosine, a neuromodulator that …
Astrocytes Mount Complex Responses to AD. They Change Over …
Dec 5, 2024 · This is an impressive study by Serrano-Pozo, Hyman, Das and colleagues that explores astrocyte transcriptomic molecular programs in aging and Alzheimer’s Disease. …
Alleviating symptoms of neurodegenerative disorders by astrocyte ...
Oct 4, 2023 · The development of an adeno-associated virus (AAV)-mediated strategy for astrocyte-specific overexpression of TMEM164 offers a novel therapeutic target and approach …
Astrocyte transcriptomic changes along the spatiotemporal …
Dec 6, 2024 · Two different reactive astrocyte clusters showed enrichment for genes that were positively correlated with the degree of p-tau pathology, suggesting that these astrocyte …
GPCR signaling gates astrocyte responsiveness to …
Jun 6, 2025 · Collectively, these papers highlight the critical and diverse roles of astrocytes in mediating the effects of norepinephrine, and related neuromodulators such as tyramine and …
Latest From GNPC: APOE4 Ages Astrocytes, Cripples Energy …
Astrocyte Age Affects APOE’s Impact. Having extremely young (left) or normally aged (middle) astrocytes blunts the ill effects of one (yellow) or two (orange) E4 alleles, while extremely old …
Astrocyte reactivity influences amyloid-β effects on tau
Jun 2, 2023 · Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease. Nat Med. 2023 Jul;29 (7):1775-1781. Epub 2023 May 29 PubMed.
Astrocyte Reactivity: Opposing States Emerge | ALZFORUM
Jun 30, 2022 · The researchers found evidence for both astrocyte states—which they called IL-1/IL-6 responsive and TNF/IFN responsive—in other published datasets, including in response …
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
Mar 7, 2025 · EphA4 inhibition counteracted both astrocyte reactivity and synaptic engulfment. EphA4 expression rose in both neurons and astrocytes with worsening amyloidosis, but was …
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · Transcriptomics study surveyed six brain regions in people with or without AD. Reelin-expressing neurons were less abundant in AD. Vulnerable neurons in different brain …